Ontology highlight
ABSTRACT:
SUBMITTER: Severyn CJ
PROVIDER: S-EPMC2988867 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Severyn Christopher J CJ Rotwein Peter P
Genomics 20100919 6
Repulsive guidance molecule c (RGMc; gene symbol: Hfe2) plays a critical role in iron metabolism. Inactivating mutations cause juvenile hemochromatosis, a severe iron overload disorder. Understanding mechanisms controlling RGMc biosynthesis has been hampered by minimal information about the RGMc gene. Here we define the structure, examine the evolution, and establish mechanisms of regulation of the mouse RGMc gene. RGMc is a 4-exon gene that undergoes alternative RNA splicing to yield 3 mRNAs wi ...[more]