Ontology highlight
ABSTRACT:
SUBMITTER: Liao TL
PROVIDER: S-EPMC2989104 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20101005 22
Influenza A virus RNA replication requires an intricate regulatory network involving viral and cellular proteins. In this study, we examined the roles of cellular ubiquitinating/deubiquitinating enzymes (DUBs). We observed that downregulation of a cellular deubiquitinating enzyme USP11 resulted in enhanced virus production, suggesting that USP11 could inhibit influenza virus replication. Conversely, overexpression of USP11 specifically inhibited viral genomic RNA replication, and this inhibition ...[more]