Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Tornero C
PROVIDER: S-EPMC2989110 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Fernández-Tornero Carlos C Böttcher Bettina B Rashid Umar Jan UJ Steuerwald Ulrich U Flörchinger Beate B Devos Damien P DP Lindner Doris D Müller Christoph W CW
The EMBO journal 20101022 22
RNA polymerase (Pol) III is responsible for the transcription of genes encoding small RNAs, including tRNA, 5S rRNA and U6 RNA. Here, we report the electron cryomicroscopy structures of yeast Pol III at 9.9 Å resolution and its elongation complex at 16.5 Å resolution. Particle sub-classification reveals prominent EM densities for the two Pol III-specific subcomplexes, C31/C82/C34 and C37/C53, that can be interpreted using homology models. While the winged-helix-containing C31/C82/C34 subcomplex ...[more]