Ontology highlight
ABSTRACT:
SUBMITTER: Feig M
PROVIDER: S-EPMC3805506 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Feig Michael M Burton Zachary F ZF
Proteins 20100201 2
The structural dynamics in eukaryotic RNA polymerase II (RNAPII) is described from computational normal mode analysis based on a series of crystal structures of pre- and post-translocated states with open and closed trigger loops. Conserved modes are identified that involve translocation of the nucleic acid complex coupled to motions of the enzyme, in particular in the clamp and jaw domains of RNAPII. A combination of these modes is hypothesized to be involved during active transcription. The NM ...[more]