Ontology highlight
ABSTRACT:
SUBMITTER: Shaw RL
PROVIDER: S-EPMC2990206 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Shaw Rachael L RL Kohlmaier Alexander A Polesello Cédric C Veelken Cornelia C Edgar Bruce A BA Tapon Nicolas N
Development (Cambridge, England) 20101110 24
Intestinal stem cells (ISCs) in the adult Drosophila midgut proliferate to self-renew and to produce differentiating daughter cells that replace those lost as part of normal gut function. Intestinal stress induces the activation of Upd/Jak/Stat signalling, which promotes intestinal regeneration by inducing rapid stem cell proliferation. We have investigated the role of the Hippo (Hpo) pathway in the Drosophila intestine (midgut). Hpo pathway inactivation in either the ISCs or the differentiated ...[more]