Ontology highlight
ABSTRACT:
SUBMITTER: Ma H
PROVIDER: S-EPMC6826283 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ma Hubing H Zhao Huiqing H Liu Fuli F Zhao Hang H Kong Ruiyan R Shi Lin L Wei Min M Li Zhouhua Z
Biology open 20191018 10
Tissue homeostasis is maintained by differentiated progeny of residential stem cells. Both extrinsic signals and intrinsic factors play critical roles in the proliferation and differentiation of adult intestinal stem cells (ISCs). However, how extrinsic signals are transduced into ISCs still remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, negatively regulates progenitor proliferation and differentiation to maintain midgut homeostasis under phy ...[more]