Epithelial dynamics of pancreatic branching morphogenesis.
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ABSTRACT:
SUBMITTER: Villasenor A
PROVIDER: S-EPMC2990215 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Epithelial dynamics of pancreatic branching morphogenesis.
Villasenor Alethia A Chong Diana C DC Henkemeyer Mark M Cleaver Ondine O
Development (Cambridge, England) 20101201 24
The mammalian pancreas is a highly branched gland, essential for both digestion and glucose homeostasis. Pancreatic branching, however, is poorly understood, both at the ultrastructural and cellular levels. In this article, we characterize the morphogenesis of pancreatic branches, from gross anatomy to the dynamics of their epithelial organization. We identify trends in pancreatic branch morphology and introduce a novel mechanism for branch formation, which involves transient epithelial stratifi ...[more]
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