Ontology highlight
ABSTRACT:
SUBMITTER: Scheele CL
PROVIDER: S-EPMC6097610 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Scheele Colinda L G J CL Hannezo Edouard E Muraro Mauro J MJ Zomer Anoek A Langedijk Nathalia S M NS van Oudenaarden Alexander A Simons Benjamin D BD van Rheenen Jacco J
Nature 20170130 7641
During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by proliferative terminal end buds that terminate or bifurcate with near equal probability, in a stochastic and time-invariant manner, leading to a heterogeneous epithelial network. We s ...[more]