Ontology highlight
ABSTRACT:
SUBMITTER: Zeng Y
PROVIDER: S-EPMC2990269 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Zeng Yi Y Cheng Lingguo L Chen Huashuai H Cao Huiqing H Hauser Elizabeth R ER Liu Yuzhi Y Xiao Zhenyu Z Tan Qihua Q Tian Xiao-Li XL Vaupel James W JW
The journals of gerontology. Series A, Biological sciences and medical sciences 20100930 12
Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese), this article contributes biodemographic insights and syntheses concerning the magnitude of effects of the FOXO genotypes on longevity. We also estimate independent and joint effects of the genotypes of FOXO1A and FOXO3A genes on long-term survival, considering carrying or not-carrying the minor allele of the single-nucleotide polymorphism of another relevant gene. We found substantial gender differences in the in ...[more]