Ontology highlight
ABSTRACT:
SUBMITTER: Mouchiroud L
PROVIDER: S-EPMC3753670 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Mouchiroud Laurent L Houtkooper Riekelt H RH Moullan Norman N Katsyuba Elena E Ryu Dongryeol D Cantó Carles C Mottis Adrienne A Jo Young-Suk YS Viswanathan Mohan M Schoonjans Kristina K Guarente Leonard L Auwerx Johan J
Cell 20130701 2
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further reduction in worm lifespan. Conversely, genetic or pharmacological restoration of NAD(+) prevents age-associated metabolic decline and promotes longevity in worms. These effects are dependent upon the protein deacetylase sir-2.1 and involve the in ...[more]