Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2991105 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Liu Yang Y Abdel Samad Omar O Zhang Ling L Duan Bo B Tong Qingchun Q Lopes Claudia C Ji Ru-Rong RR Lowell Bradford B BB Ma Qiufu Q
Neuron 20101101 3
Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-dependent synaptic glutamate release from mainly Nav1.8-expressing nociceptors was abolished. These mice showed deficits in pain behaviors, including mechanical pain, heat pain, capsaicin-evoked pain, inflammatory pain, and neuropathic pain. The pain deficits were accompanied by greatly enhanced itching, as suggested by ...[more]