Toll-like receptor 7 mediates pruritus.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu T
PROVIDER: S-EPMC2991508 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Toll-like receptor 7 mediates pruritus.
Liu Tong T Xu Zhen-Zhong ZZ Park Chul-Kyu CK Berta Temugin T Ji Ru-Rong RR
Nature neuroscience 20101031 12
Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice. Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions. ...[more]
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