Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC2992822 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Li Gang G Bien-Ly Nga N Andrews-Zwilling Yaisa Y Xu Qin Q Bernardo Aubrey A Ring Karen K Halabisky Brian B Deng Changhui C Mahley Robert W RW Huang Yadong Y
Cell stem cell 20091201 6
Apolipoprotein (apo) E, a polymorphic protein with three isoforms (apoE2, apoE3, and apoE4), is essential for lipid homeostasis. Carriers of apoE4 are at higher risk for developing Alzheimer's disease. We have investigated adult neurogenesis in mice with knockout (KO) for apoE or with knockin (KI) alleles for human apoE3 or apoE4, and we report that neurogenesis is reduced in both apoE-KO and apoE4-KI mice. In apoE-KO mice, increased BMP signaling promoted glial differentiation at the expense of ...[more]