Ontology highlight
ABSTRACT:
SUBMITTER: Bao H
PROVIDER: S-EPMC5689456 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Bao Hechen H Asrican Brent B Li Weidong W Gu Bin B Wen Zhexing Z Lim Szu-Aun SA Haniff Isaac I Ramakrishnan Charu C Deisseroth Karl K Philpot Benjamin B Song Juan J
Cell stem cell 20171101 5
The quiescence of adult neural stem cells (NSCs) is regulated by local parvalbumin (PV) interneurons within the dentate gyrus (DG). Little is known about how local PV interneurons communicate with distal brain regions to regulate NSCs and hippocampal neurogenesis. Here, we identify GABAergic projection neurons from the medial septum (MS) as the major afferents to dentate PV interneurons. Surprisingly, dentate PV interneurons are depolarized by GABA signaling, which is in sharp contrast to most m ...[more]