Ontology highlight
ABSTRACT:
SUBMITTER: Bjerke SL
PROVIDER: S-EPMC2993110 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Bjerke Susan L SL Roller Richard J RJ
Virology 20060119 2
Cells infected with wild type HSV-1 showed significant lamin A/C and lamin B rearrangement, while UL34-null virus-infected cells exhibited few changes in lamin localization, indicating that UL34 is necessary for lamin disruption. During HSV infection, US3 limited the development of disruptions in the lamina, since cells infected with a US3-null virus developed large perforations in the lamin layer. US3 regulation of lamin disruption does not correlate with the induction of apoptosis. Expression ...[more]