Ontology highlight
ABSTRACT:
SUBMITTER: Khadivjam B
PROVIDER: S-EPMC9892522 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Khadivjam Bita B Bonneil Éric É Thibault Pierre P Lippé Roger R
Communications biology 20230201 1
DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear DNA replicating virus, redirects DDX3X to the nuclear envelope where it surprisingly modulates the exit of newly assembled viral particles. DDX3X depletion also leads to an accumulation of virions in intranuclear herniations. Mechanistically, we show that DDX3X physically and functionally interacts with the virally encoded nuclear ...[more]