Ontology highlight
ABSTRACT:
SUBMITTER: D'Cruz LM
PROVIDER: S-EPMC2993240 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
D'Cruz Louise M LM Knell Jamie J Fujimoto Jessica K JK Goldrath Ananda W AW
Nature immunology 20100214 3
E proteins are basic helix-loop-helix transcription factors that regulate many key aspects of lymphocyte development. Thymocytes express multiple E proteins that are thought to provide cooperative and compensatory functions crucial for T cell differentiation. Contrary to that, we report here that the E protein HEB was uniquely required at the CD4(+)CD8(+) double-positive (DP) stage of T cell development. Thymocytes lacking HEB showed impaired survival, failed to make rearrangements of variable-a ...[more]