Ontology highlight
ABSTRACT:
SUBMITTER: Khan MQ
PROVIDER: S-EPMC2993331 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Khan M Qasim MQ Sweeting Braden B Mulligan Vikram Khipple VK Arslan Pharhad Eli PE Cashman Neil R NR Pai Emil F EF Chakrabartty Avijit A
Proceedings of the National Academy of Sciences of the United States of America 20101101 46
Prion diseases occur when the normally α-helical prion protein (PrP) converts to a pathological β-structured state with prion infectivity (PrP(Sc)). Exposure to PrP(Sc) from other mammals can catalyze this conversion. Evidence from experimental and accidental transmission of prions suggests that mammals vary in their prion disease susceptibility: Hamsters and mice show relatively high susceptibility, whereas rabbits, horses, and dogs show low susceptibility. Using a novel approach to quantify co ...[more]