Ontology highlight
ABSTRACT:
SUBMITTER: Mallery DL
PROVIDER: S-EPMC2993423 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Mallery Donna L DL McEwan William A WA Bidgood Susanna R SR Towers Greg J GJ Johnson Chris M CM James Leo C LC
Proceedings of the National Academy of Sciences of the United States of America 20101102 46
Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular immune response that disables virions in the cytosol. We have discovered that cells possess a cytosolic IgG receptor, tripartite motif-containing 21 (TRIM21), which binds to antibodies with a higher affinity than any other IgG receptor in the human body. TRIM21 rapidly recruits t ...[more]