Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
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ABSTRACT:
SUBMITTER: Bierut LJ
PROVIDER: S-EPMC2993565 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
Trends in pharmacological sciences 20091105 1
Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine ...[more]
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