Ontology highlight
ABSTRACT:
SUBMITTER: Shan J
PROVIDER: S-EPMC2993575 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Shan Jian J Kushnir Alexander A Betzenhauser Matthew J MJ Reiken Steven S Li Jingdong J Lehnart Stephan E SE Lindegger Nicolas N Mongillo Marco M Mohler Peter J PJ Marks Andrew R AR
The Journal of clinical investigation 20101122 12
During the classic "fight-or-flight" stress response, sympathetic nervous system activation leads to catecholamine release, which increases heart rate and contractility, resulting in enhanced cardiac output. Catecholamines bind to β-adrenergic receptors, causing cAMP generation and activation of PKA, which phosphorylates multiple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2) required for muscle contraction. PKA phosphorylation of RyR2 enhances ...[more]