Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
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ABSTRACT:
SUBMITTER: Ben-Batalla I
PROVIDER: S-EPMC2993584 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Ben-Batalla Isabel I Seoane Samuel S Garcia-Caballero Tomas T Gallego Rosalia R Macia Manuel M Gonzalez Luis O LO Vizoso Francisco F Perez-Fernandez Roman R
The Journal of clinical investigation 20101108 12
The Pit-1 transcription factor (also know as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary in mammals and is a transcriptional activator for pituitary gene transcription. Increased expression of Pit-1 has been reported in human tumorigenic breast cells. Here, we found that Pit-1 overexpression or knockdown in human breast cancer cell lines induced profound phenotypic changes in the expression of proteins involved in cell proliferation, apopt ...[more]
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