Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramani A
PROVIDER: S-EPMC2994316 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Balasubramani Anand A Shibata Yoichiro Y Crawford Gregory E GE Baldwin Albert S AS Hatton Robin D RD Weaver Casey T CT
Immunity 20100701 1
Distal cis-regulatory elements play essential roles in the T lineage-specific expression of cytokine genes. We have mapped interactions of three trans-acting factors-NF-kappaB, STAT4, and T-bet-with cis elements in the Ifng locus. We find that RelA is critical for optimal Ifng expression and is differentially recruited to multiple elements contingent upon T cell receptor (TCR) or interleukin-12 (IL-12) plus IL-18 signaling. RelA recruitment to at least four elements is dependent on T-bet-depende ...[more]