Ontology highlight
ABSTRACT:
SUBMITTER: Collins PL
PROVIDER: S-EPMC2923829 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Collins Patrick L PL Chang Shaojing S Henderson Melodie M Soutto Mohammed M Davis Georgia M GM McLoed Allyson G AG Townsend Michael J MJ Glimcher Laurie H LH Mortlock Douglas P DP Aune Thomas M TM
Journal of immunology (Baltimore, Md. : 1950) 20100623 3
Genes, such as IFNG, which are expressed in multiple cell lineages of the immune system, may employ a common set of regulatory elements to direct transcription in multiple cell types or individual regulatory elements to direct expression in individual cell lineages. By employing a bacterial artificial chromosome transgenic system, we demonstrate that IFNG employs unique regulatory elements to achieve lineage-specific transcriptional control. Specifically, a one 1-kb element 30 kb upstream of IFN ...[more]