Ontology highlight
ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC2994650 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yao Yucheng Y Bennett Brian J BJ Wang Xuping X Rosenfeld Michael E ME Giachelli Cecilia C Lusis Aldons J AJ Boström Kristina I KI
Circulation research 20100624 4
<h4>Rationale</h4>The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall.<h4>Objective</h4>To investigate the effect of altered expression of matrix Gla protein (MGP), an inhibitor of BMP, on vascular disease.<h4>Methods and results</h4>We used MGP transgenic or MGP-deficient mice bred to apolipoprotein E mice, a model of atherosclerosis. MGP overexpression reduced vascular BMP activity, atheroscler ...[more]