Ontology highlight
ABSTRACT:
SUBMITTER: Hartman TR
PROVIDER: S-EPMC2995164 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Hartman Tiffiney R TR Zinshteyn Daniel D Schofield Heather K HK Nicolas Emmanuelle E Okada Ami A O'Reilly Alana M AM
The Journal of cell biology 20101122 5
Stem cells depend on signals from cells within their microenvironment, or niche, as well as factors secreted by distant cells to regulate their maintenance and function. Here we show that Boi, a Hedgehog (Hh)-binding protein, is a novel suppressor of proliferation of follicle stem cells (FSCs) in the Drosophila ovary. Hh is expressed in apical cells, distant from the FSC niche, and diffuses to reach FSCs, where it promotes FSC proliferation. We show that Boi is expressed in apical cells and exer ...[more]