Ontology highlight
ABSTRACT:
SUBMITTER: Graham DB
PROVIDER: S-EPMC2995352 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Graham Daniel B DB Akilesh Holly M HM Gmyrek Grzegorz B GB Piccio Laura L Gilfillan Susan S Sim Julia J Belizaire Roger R Carrero Javier A JA Wang Yinan Y Blaufuss Gregory S GS Sandoval Gabriel G Fujikawa Keiko K Cross Anne H AH Russell John H JH Cella Marina M Swat Wojciech W
Blood 20100715 17
Immature dendritic cells (DCs) specialize in antigen capture and maintain a highly dynamic pool of intracellular major histocompatibility complex class II (MHCII) that continuously recycles from peptide loading compartments to the plasma membrane and back again. This process facilitates sampling of environmental antigens for presentation to T helper cells. Here, we show that a signaling pathway mediated by the DC immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors (DAP12 an ...[more]