Ontology highlight
ABSTRACT:
SUBMITTER: Masuda K
PROVIDER: S-EPMC2995445 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Masuda Keiji K Mori Hiromi H Ohara Osamu O Nakayama Manabu M Wang Ji-Yang JY Burrows Peter D PD
Cellular immunology 20100101 1
Fc receptor-like A (FCRLA) and FCRLB have homology to the transmembrane FCRL family members (FCRL 1-6) and to the conventional receptors for the Fc portion of immunoglobulin, but uniquely are cytosolic proteins expressed in B cells. Here we describe the phenotype of Fcrlb-gene targeted mice. B cell development and in vitro responses are normal; however, antibody responses to a T-dependent antigen are elevated. The gene encoding the inhibitory FcγRIIb is located nearby Fcrlb. Although Fcrlb-gene ...[more]