Lipid-induced insulin resistance: unravelling the mechanism.
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ABSTRACT:
SUBMITTER: Samuel VT
PROVIDER: S-EPMC2995547 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Lipid-induced insulin resistance: unravelling the mechanism.
Samuel Varman T VT Petersen Kitt Falk KF Shulman Gerald I GI
Lancet (London, England) 20100601 9733
Insulin resistance has long been associated with obesity. More than 40 years ago, Randle and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles through inhibition of glycolysis at key points. However, work over the past two decades has shown that lipid-induced insulin resistance in skeletal muscle stems from defects in insulin-stimulated glucose transport activity. The steatotic liver is also resistant to insulin in terms of inhibition of hepatic glucose product ...[more]
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