Ontology highlight
ABSTRACT:
SUBMITTER: Bick MJ
PROVIDER: S-EPMC2995723 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Bick Matthew J MJ Banik Jacob J JJ Darst Seth A SA Brady Sean F SF
Acta crystallographica. Section D, Biological crystallography 20101116 Pt 12
The TEG gene cluster was recently isolated from an environmental DNA library and is predicted to encode the biosynthesis of a polysulfated glycopeptide congener. Three closely related sulfotransferases found in the TEG gene cluster (Teg12, Teg13 and Teg14) have been shown to sulfate the teicoplanin aglycone at three unique sites. Crystal structures of the first sulfotransferase from the TEG cluster, Teg12, in complex with the teicoplanin aglycone and its desulfated cosubstrate PAP have recently ...[more]