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Metalated aziridines for cross-coupling with aryl and alkenyl halides via palladium catalysis.

ABSTRACT: The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related to l-furanomycin.

SUBMITTER: Nelson JM

PROVIDER: S-EPMC2996137 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Metalated aziridines for cross-coupling with aryl and alkenyl halides via palladium catalysis.

Nelson John M JM Vedejs Edwin E

Organic letters 20101014 22

The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related to l-furanomycin. ...[more]

PMID: 20945857

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