Ontology highlight
ABSTRACT:
SUBMITTER: Ali A
PROVIDER: S-EPMC2996262 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20101101 21
A series of new HIV-1 protease inhibitors with the hydroxyethylamine core and different phenyloxazolidinone P2 ligands were designed and synthesized. Variation of phenyl substitutions at the P2 and P2' moieties significantly affected the binding affinity and antiviral potency of the inhibitors. In general, compounds with 2- and 4-substituted phenyloxazolidinones at P2 exhibited lower binding affinities than 3-substituted analogues. Crystal structure analyses of ligand-enzyme complexes revealed d ...[more]