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ABSTRACT:
SUBMITTER: Agapkina J
PROVIDER: S-EPMC4018115 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Agapkina Julia J Zatsepin Timofei T Knyazhanskaya Ekaterina E Mouscadet Jean-Francois JF Gottikh Marina M
ACS medicinal chemistry letters 20110419 7
Integration of human immunodeficiency virus type 1 DNA into an infected cell genome is one of the key steps of the viral replication cycle. Therefore, viral enzyme integrase, which realizes the integration, represents an attractive and validated target for the development of new antiviral drugs. In this paper, the anti-integrase activity of a series of conjugates of single-stranded oligonucleotides with hydrophobic molecules was tested, and the structure-activity relationships were also analyzed ...[more]