Ontology highlight
ABSTRACT:
SUBMITTER: Magill ST
PROVIDER: S-EPMC2996687 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Magill Stephen T ST Cambronne Xiaolu A XA Luikart Bryan W BW Lioy Daniel T DT Leighton Barbara H BH Westbrook Gary L GL Mandel Gail G Goodman Richard H RH
Proceedings of the National Academy of Sciences of the United States of America 20101108 47
Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and their integration into the dentate network. Among its many targets, the transcription factor CREB activates expression of a gene locus that produces two microRNAs, miR-132 and miR-212. In cultured cortical and hippocampal neurons, miR-132 functions downstream from CREB to mediate activity-dependent dendritic growth ...[more]