Ontology highlight
ABSTRACT:
SUBMITTER: Carlon M
PROVIDER: S-EPMC2997580 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Carlon Marianne M Toelen Jaan J Van der Perren Anke A Vandenberghe Luk H LH Reumers Veerle V Sbragia Lourenço L Gijsbers Rik R Baekelandt Veerle V Himmelreich Uwe U Wilson James M JM Deprest Jan J Debyser Zeger Z
Molecular therapy : the journal of the American Society of Gene Therapy 20100727 12
Fetal gene therapy is one of the possible new therapeutic strategies for congenital or perinatal diseases with high mortality or morbidity. We developed a novel delivery strategy to inject directly into the fetal mouse trachea. Intratracheal (i.t.) injection at embryonic day 18 (E18) was more efficient in targeting the fetal lung than conventional intra-amniotic (i.a.) delivery. Viral vectors derived from adeno-associated virus serotype 6.2, with tropism for the airway epithelium and not earlier ...[more]