Ontology highlight
ABSTRACT:
SUBMITTER: Shibata SB
PROVIDER: S-EPMC5575199 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Shibata Seiji B SB Yoshimura Hidekane H Ranum Paul T PT Goodwin Alexander T AT Smith Richard J H RJH
Scientific reports 20170829 1
Gene therapy for genetic deafness is a promising approach by which to prevent hearing loss or to restore hearing after loss has occurred. Although a variety of direct approaches to introduce viral particles into the inner ear have been described, presumed physiological barriers have heretofore precluded investigation of systemic gene delivery to the cochlea. In this study, we sought to characterize systemic delivery of a rAAV2/9 vector as a non-invasive means of cochlear transduction. In wild-ty ...[more]