Ontology highlight
ABSTRACT:
SUBMITTER: Kane NM
PROVIDER: S-EPMC2997595 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20101026 12
Retroviral vectors remain the most efficient and widely applied system for induction of pluripotency. However, mutagenic effects have been documented in both laboratory and clinical gene therapy studies, principally as a result of dysregulated host gene expression in the proximity of defined integration sites. Here, we report that cells with characteristics of pluripotent stem cells can be produced from normal human fibroblasts in the absence of reprogramming transcription factors (TFs) during l ...[more]