Ontology highlight
ABSTRACT:
SUBMITTER: Edwards AL
PROVIDER: S-EPMC2997738 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Edwards Andrea L AL Batey Robert T RT
Journal of molecular biology 20081105 3
Riboswitches are noncoding RNA elements that are commonly found in the 5'-untranslated region of bacterial mRNA. Binding of a small-molecule metabolite to the riboswitch aptamer domain guides the folding of the downstream sequence into one of two mutually exclusive secondary structures that directs gene expression. The purine riboswitch family, which regulates aspects of purine biosynthesis and transport, contains three distinct classes that specifically recognize guanine/hypoxanthine, adenine, ...[more]