Ontology highlight
ABSTRACT:
SUBMITTER: Spitale RC
PROVIDER: S-EPMC2670106 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Spitale Robert C RC Torelli Andrew T AT Krucinska Jolanta J Bandarian Vahe V Wedekind Joseph E JE
The Journal of biological chemistry 20090304 17
Riboswitches are RNA elements that control gene expression through metabolite binding. The preQ(1) riboswitch exhibits the smallest known ligand-binding domain and is of interest for its economical organization and high affinity interactions with guanine-derived metabolites required to confer tRNA wobbling. Here we present the crystal structure of a preQ(1) aptamer domain in complex with its precursor metabolite preQ(0). The structure is highly compact with a core that features a stem capped by ...[more]