Ontology highlight
ABSTRACT:
SUBMITTER: Friberg A
PROVIDER: S-EPMC2998725 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Friberg Anders A Oddone Anna A Klymenko Tetyana T Müller Jürg J Sattler Michael M
Protein science : a publication of the Protein Society 20101001 10
Post-translational modifications of histone tails are among the most prominent epigenetic marks and play a critical role in transcriptional control at the level of chromatin. The Polycomblike (Pcl) protein is part of a histone methyltransferase complex (Pcl-PRC2) responsible for high levels of histone H3 K27 trimethylation. Studies in Drosophila larvae suggest that Pcl is required for anchoring Pcl-PRC2 at target genes, but how this is achieved is unknown. Pcl comprises a Tudor domain and two PH ...[more]