H2S signals through protein S-sulfhydration.
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ABSTRACT:
SUBMITTER: Mustafa AK
PROVIDER: S-EPMC2998899 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
H2S signals through protein S-sulfhydration.
Mustafa Asif K AK Gadalla Moataz M MM Sen Nilkantha N Kim Seyun S Mu Weitong W Gazi Sadia K SK Barrow Roxanne K RK Yang Guangdong G Wang Rui R Snyder Solomon H SH
Science signaling 20091110 96
Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many liver proteins, including actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions. Sulfhydration augments GAPDH activity and enhances act ...[more]
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