Ontology highlight
ABSTRACT:
SUBMITTER: Dardalhon V
PROVIDER: S-EPMC2999006 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Dardalhon Valérie V Awasthi Amit A Kwon Hyoung H Galileos George G Gao Wenda W Sobel Raymond A RA Mitsdoerffer Meike M Strom Terry B TB Elyaman Wassim W Ho I-Cheng IC Khoury Samia S Oukka Mohamed M Kuchroo Vijay K VK
Nature immunology 20081109 12
Transcription factor Foxp3 is critical for generating regulatory T cells (T(reg) cells). Transforming growth factor-beta (TGF-beta) induces Foxp3 and suppressive T(reg) cells from naive T cells, whereas interleukin 6 (IL-6) inhibits the generation of inducible T(reg) cells. Here we show that IL-4 blocked the generation of TGF-beta-induced Foxp3(+) T(reg) cells and instead induced a population of T helper cells that produced IL-9 and IL-10. The IL-9(+)IL-10(+) T cells demonstrated no regulatory p ...[more]