A critical role of neural-specific JNK3 for ischemic apoptosis.
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ABSTRACT:
SUBMITTER: Kuan CY
PROVIDER: S-EPMC299947 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Publications
A critical role of neural-specific JNK3 for ischemic apoptosis.
Kuan Chia-Yi CY Whitmarsh Alan J AJ Yang Derek D DD Liao Guanghong G Schloemer Aryn J AJ Dong Chen C Bao Jue J Banasiak Kenneth J KJ Haddad Gabriel G GG Flavell Richard A RA Davis Roger J RJ Rakic Pasko P
Proceedings of the National Academy of Sciences of the United States of America 20031201 25
c-Jun N-terminal kinase (JNK) signaling is an important contributor to stress-induced apoptosis, but it is unclear whether JNK and its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia. Here we show that JNK1 is the major isoform responsible for the high level of basal JNK activity in the brain. In contrast, targeted deletion of Jnk3 not only reduces the stress-induced JNK activity, but also protects mice from brain injury after cerebral ischemia-hypoxia. The downstream me ...[more]
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