Dataset Information

Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

ABSTRACT:

Aim

To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.

Methods

Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.

Results

There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.

Conclusion

This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.

SUBMITTER: Yang MD

PROVIDER: S-EPMC2999679 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

Yang Mei-Due MD Tsai Ru-Yin RY Liu Chiu-Shong CS Chang Chao-Hsiang CH Wang Hwei-Chung HC Tsou Yung-An YA Wang Chung-Hsing CH Lin Cheng-Chieh CC Shyue Song-Kun SK Bau Da-Tian DT

World journal of gastrointestinal oncology 20100801 8

<h4>Aim</h4>To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.<h4>Methods</h4>Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.<h4>Results</h4>There were significant differences between ...[more]

PMID: 21160894

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Project description:BackgroundOral squamous cell carcinoma (OSCC) is the fourth leading cause of male cancer death in Taiwan. Exposure to environmental carcinogens is the primary risk factor for developing OSCC. CD44, a well-known tumor marker, plays a crucial role in tumor cell differentiation, invasion, and metastasis. This study investigated CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics.Methodology/principal findingsReal-time polymerase chain reaction (PCR) was used to analyze 6 SNPs of CD44 in 599 patients with oral cancer and 561 cancer-free controls. We determined that the CD44 rs187115 polymorphism carriers with the genotype AG, GG, or AG+GG were associated with oral cancer susceptibility. Among 731 smokers, CD44 polymorphisms carriers with the betel-nut chewing habit had a 10.30-37.63-fold greater risk of having oral cancer compared to CD44 wild-type (WT) carriers without the betel-nut chewing habit. Among 552 betel-nut chewers, CD44 polymorphisms carriers who smoked had a 4.23-16.11-fold greater risk of having oral cancer compared to those who carried the WT but did not smoke. Finally, we also observed that the stage III and IV oral cancer patients had higher frequencies of CD44 rs187115 polymorphisms with the variant genotype (AG+GG) compared with the wild-type (WT) carriers.ConclusionOur results suggest that gene-environment interactions between the CD44 polymorphisms and betel quid chewing and tobacco smoking increase the susceptibility to oral cancer development. Patients with CD44 rs187115 variant genotypes (AG+GG) were correlated with a higher risk of oral cancer development, and these patients may possess greater chemoresistance to advanced- to late-stage oral cancer than WT carriers do. The CD44 rs187115 polymorphism has potential predictive significance in oral carcinogenesis and also may be applied as factors to predict the clinical stage in OSCC patients.

Dataset Information

Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

Aim

Methods

Results

Conclusion

Publications

Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

Similar Datasets

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