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Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.

ABSTRACT: BACKGROUND/AIM:The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese. MATERIALS AND METHODS:A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS:Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls. CONCLUSION:IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese.

SUBMITTER: Chu CN

PROVIDER: S-EPMC7279797 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature

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Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.

Chu Chin-Nan CN Wang Yun-Chi YC Chang Wen-Shin WS Wang Zhi-Hong ZH Liu Liang-Chih LC Wang Shao-Chun SC Lin Cheng-Chieh CC Liu Ting-Yuan TY Chang Jan-Gowth JG Tsai Chia-Wen CW Yu Chien-Chih CC Bau DA-Tian DT

In vivo (Athens, Greece) 20200501 3

<h4>Background/aim</h4>The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese.<h4>Materials and methods</h4>A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.<h4>Results</h4>Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were n ...[more]

PMID: 32354899

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