Ontology highlight
ABSTRACT:
SUBMITTER: Chartrel N
PROVIDER: S-EPMC299975 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Chartrel Nicolas N Dujardin Cynthia C Anouar Youssef Y Leprince Jérôme J Decker Annick A Clerens Stefan S Do-Régo Jean-Claude JC Vandesande Frans F Llorens-Cortes Catherine C Costentin Jean J Beauvillain Jean-Claude JC Vaudry Hubert H
Proceedings of the National Academy of Sciences of the United States of America 20031201 25
A neuropeptide was isolated from a frog brain extract by HPLC purification and characterized by mass spectrometry. This 26-aa neuropeptide, which belongs to the RFamide peptide family, was designated 26RFa, and its primary structure was established as VGTALGSLAEELNGYNRKKGGFSFRF-NH2. Research in databases revealed the presence of sequences homologous to frog 26RFa in the human genome and in rat ESTs. On the basis of this sequence information, the cDNAs encoding the human and rat 26RFa precursors ...[more]