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Partitioning of lipids at domain boundaries in model membranes.

ABSTRACT: Line-active molecules ("linactants") that bind to the boundary interface between different fluid lipid domains in membranes have a strong potential as regulators of the lateral heterogeneity that is important for many biological processes. Here, we use molecular dynamics simulations in combination with a coarse-grain model that retains near-atomic resolution to identify lipid species that can act as linactants in a model membrane that is segregated into two lipid domains of different fluidity. Our simulations predict that certain hybrid saturated/unsaturated chain lipids can bind to the interface and lower the line tension, whereas cone-shaped lysolipids have a less pronounced effect.

SUBMITTER: Schafer LV

PROVIDER: S-EPMC3000497 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Partitioning of lipids at domain boundaries in model membranes.

Schäfer Lars V LV Marrink Siewert J SJ

Biophysical journal 20101201 12

Line-active molecules ("linactants") that bind to the boundary interface between different fluid lipid domains in membranes have a strong potential as regulators of the lateral heterogeneity that is important for many biological processes. Here, we use molecular dynamics simulations in combination with a coarse-grain model that retains near-atomic resolution to identify lipid species that can act as linactants in a model membrane that is segregated into two lipid domains of different fluidity. O ...[more]

PMID: 21156123

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Dataset Information

Partitioning of lipids at domain boundaries in model membranes.

Publications

Partitioning of lipids at domain boundaries in model membranes.

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