Clustered diffusion of integrins.
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ABSTRACT:
SUBMITTER: Lepzelter D
PROVIDER: S-EPMC3000510 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Clustered diffusion of integrins.
Lepzelter David D Zaman Muhammad H MH
Biophysical journal 20101201 12
We discuss the diffusion of clusters of integrins (and other similar membrane proteins) on a cell membrane with a cortical cytoskeleton. We argue that protein clusters--in contrast with normal oligomers, which are forced to pass through cytoskeletal barriers all at once--should be treated essentially as many-legged random walkers that can pass through a cytoskeletal barrier by putting one leg at a time through the fence. We present the mathematics that should describe the phenomenon, which resul ...[more]
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