Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
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ABSTRACT:
SUBMITTER: Stolk L
PROVIDER: S-EPMC3000545 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
Stolk Lisette L Zhai Guangju G van Meurs Joyce B J JB Verbiest Michael M P J MM Visser Jenny A JA Estrada Karol K Rivadeneira Fernando F Williams Frances M FM Cherkas Lynn L Deloukas Panos P Soranzo Nicole N de Keyzer Jules J JJ Pop Victor J M VJ Lips Paul P Lebrun Corinne E I CE van der Schouw Yvonne T YT Grobbee Diederick E DE Witteman Jacqueline J Hofman Albert A Pols Huibert A P HA Laven Joop S E JS Spector Tim D TD Uitterlinden André G AG
Nature genetics 20090517 6
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important ris ...[more]
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