Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
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ABSTRACT:
SUBMITTER: Heid IM
PROVIDER: S-EPMC3000924 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Heid Iris M IM Jackson Anne U AU Randall Joshua C JC Winkler Thomas W TW Qi Lu L Steinthorsdottir Valgerdur V Thorleifsson Gudmar G Zillikens M Carola MC Speliotes Elizabeth K EK Mägi Reedik R Workalemahu Tsegaselassie T White Charles C CC Bouatia-Naji Nabila N Harris Tamara B TB Berndt Sonja I SI Ingelsson Erik E Willer Cristen J CJ Weedon Michael N MN Luan Jian'an J Vedantam Sailaja S Esko Tõnu T Kilpeläinen Tuomas O TO Kutalik Zoltán Z Li Shengxu S Monda Keri L KL Dixon Anna L AL Holmes Christopher C CC Kaplan Lee M LM Liang Liming L Min Josine L JL Moffatt Miriam F MF Molony Cliona C Nicholson George G Schadt Eric E EE Zondervan Krina T KT Feitosa Mary F MF Ferreira Teresa T Lango Allen Hana H Weyant Robert J RJ Wheeler Eleanor E Wood Andrew R AR Estrada Karol K Goddard Michael E ME Lettre Guillaume G Mangino Massimo M Nyholt Dale R DR Purcell Shaun S Smith Albert Vernon AV Visscher Peter M PM Yang Jian J McCarroll Steven A SA Nemesh James J Voight Benjamin F BF Absher Devin D Amin Najaf N Aspelund Thor T Coin Lachlan L Glazer Nicole L NL Hayward Caroline C Heard-Costa Nancy L NL Hottenga Jouke-Jan JJ Johansson Asa A Johnson Toby T Kaakinen Marika M Kapur Karen K Ketkar Shamika S Knowles Joshua W JW Kraft Peter P Kraja Aldi T AT Lamina Claudia C Leitzmann Michael F MF McKnight Barbara B Morris Andrew P AP Ong Ken K KK Perry John R B JR Peters Marjolein J MJ Polasek Ozren O Prokopenko Inga I Rayner Nigel W NW Ripatti Samuli S Rivadeneira Fernando F Robertson Neil R NR Sanna Serena S Sovio Ulla U Surakka Ida I Teumer Alexander A van Wingerden Sophie S Vitart Veronique V Zhao Jing Hua JH Cavalcanti-Proença Christine C Chines Peter S PS Fisher Eva E Kulzer Jennifer R JR Lecoeur Cecile C Narisu Narisu N Sandholt Camilla C Scott Laura J LJ Silander Kaisa K Stark Klaus K Tammesoo Mari-Liis ML Teslovich Tanya M TM Timpson Nicholas John NJ Watanabe Richard M RM Welch Ryan R Chasman Daniel I DI Cooper Matthew N MN Jansson John-Olov JO Kettunen Johannes J Lawrence Robert W RW Pellikka Niina N Perola Markus M Vandenput Liesbeth L Alavere Helene H Almgren Peter P Atwood Larry D LD Bennett Amanda J AJ Biffar Reiner R Bonnycastle Lori L LL Bornstein Stefan R SR Buchanan Thomas A TA Campbell Harry H Day Ian N M IN Dei Mariano M Dörr Marcus M Elliott Paul P Erdos Michael R MR Eriksson Johan G JG Freimer Nelson B NB Fu Mao M Gaget Stefan S Geus Eco J C EJ Gjesing Anette P AP Grallert Harald H Grässler Jürgen J Groves Christopher J CJ Guiducci Candace C Hartikainen Anna-Liisa AL Hassanali Neelam N Havulinna Aki S AS Herzig Karl-Heinz KH Hicks Andrew A AA Hui Jennie J Igl Wilmar W Jousilahti Pekka P Jula Antti A Kajantie Eero E Kinnunen Leena L Kolcic Ivana I Koskinen Seppo S Kovacs Peter P Kroemer Heyo K HK Krzelj Vjekoslav V Kuusisto Johanna J Kvaloy Kirsti K Laitinen Jaana J Lantieri Olivier O Lathrop G Mark GM Lokki Marja-Liisa ML Luben Robert N RN Ludwig Barbara B McArdle Wendy L WL McCarthy Anne A Morken Mario A MA Nelis Mari M Neville Matt J MJ Paré Guillaume G Parker Alex N AN Peden John F JF Pichler Irene I Pietiläinen Kirsi H KH Platou Carl G P CG Pouta Anneli A Ridderstråle Martin M Samani Nilesh J NJ Saramies Jouko J Sinisalo Juha J Smit Jan H JH Strawbridge Rona J RJ Stringham Heather M HM Swift Amy J AJ Teder-Laving Maris M Thomson Brian B Usala Gianluca G van Meurs Joyce B J JB van Ommen Gert-Jan GJ Vatin Vincent V Volpato Claudia B CB Wallaschofski Henri H Walters G Bragi GB Widen Elisabeth E Wild Sarah H SH Willemsen Gonneke G Witte Daniel R DR Zgaga Lina L Zitting Paavo P Beilby John P JP James Alan L AL Kähönen Mika M Lehtimäki Terho T Nieminen Markku S MS Ohlsson Claes C Palmer Lyle J LJ Raitakari Olli O Ridker Paul M PM Stumvoll Michael M Tönjes Anke A Viikari Jorma J Balkau Beverley B Ben-Shlomo Yoav Y Bergman Richard N RN Boeing Heiner H Smith George Davey GD Ebrahim Shah S Froguel Philippe P Hansen Torben T Hengstenberg Christian C Hveem Kristian K Isomaa Bo B Jørgensen Torben T Karpe Fredrik F Khaw Kay-Tee KT Laakso Markku M Lawlor Debbie A DA Marre Michel M Meitinger Thomas T Metspalu Andres A Midthjell Kristian K Pedersen Oluf O Salomaa Veikko V Schwarz Peter E H PE Tuomi Tiinamaija T Tuomilehto Jaakko J Valle Timo T TT Wareham Nicholas J NJ Arnold Alice M AM Beckmann Jacques S JS Bergmann Sven S Boerwinkle Eric E Boomsma Dorret I DI Caulfield Mark J MJ Collins Francis S FS Eiriksdottir Gudny G Gudnason Vilmundur V Gyllensten Ulf U Hamsten Anders A Hattersley Andrew T AT Hofman Albert A Hu Frank B FB Illig Thomas T Iribarren Carlos C Jarvelin Marjo-Riitta MR Kao W H Linda WH Kaprio Jaakko J Launer Lenore J LJ Munroe Patricia B PB Oostra Ben B Penninx Brenda W BW Pramstaller Peter P PP Psaty Bruce M BM Quertermous Thomas T Rissanen Aila A Rudan Igor I Shuldiner Alan R AR Soranzo Nicole N Spector Timothy D TD Syvanen Ann-Christine AC Uda Manuela M Uitterlinden André A Völzke Henry H Vollenweider Peter P Wilson James F JF Witteman Jacqueline C JC Wright Alan F AF Abecasis Gonçalo R GR Boehnke Michael M Borecki Ingrid B IB Deloukas Panos P Frayling Timothy M TM Groop Leif C LC Haritunians Talin T Hunter David J DJ Kaplan Robert C RC North Kari E KE O'Connell Jeffrey R JR Peltonen Leena L Schlessinger David D Strachan David P DP Hirschhorn Joel N JN Assimes Themistocles L TL Wichmann H-Erich HE Thorsteinsdottir Unnur U van Duijn Cornelia M CM Stefansson Kari K Cupples L Adrienne LA Loos Ruth J F RJ Barroso Inês I McCarthy Mark I MI Fox Caroline S CS Mohlke Karen L KL Lindgren Cecilia M CM
Nature genetics 20101010 11
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VE ...[more]